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KMID : 0370219960400050591
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Yakhak Hoeji
1996 Volume.40 No. 5 p.591 ~ p.598
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Spasmolytic and Anti-peptic Ulcer Activities of Crude Drugs Acting on Gastrointestinal Tract in Rats
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조승길/Cho SK
박혜란/김창종/Park HR/Kim CJ
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Abstract
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The water extracts of ten crude drugs were tested for the spasmolytic and anti-peptic ulcer activities on rat ileum smooth muscle contraction and aspirin-induced acute hemorrhagic erosive gastritis respectively. The water extract of Aurantii immaturi pericarpium(AIP)(IC50=1.5 X 1O-2g/l), Aurantii nobilis pericarpium(ANP)(IC50=2.5 X 1O-2g/l), Cyperi rhizoma(CR)(IC50=3.3 X 1O-2g/l). Linderae radix(LR) (IC50=6.8 X 1O-2g/l), Aurantii fructus immaturus(AFI)(IC50=23.3 X 1O-2g/l), Saussureae radix(SR)(IC50=13.2 X 1O-2g/l) and Ponciri fructus(PF)(IC50=23.3 X 1O-2g/l) showed inhibitory activity on the isometric contraction of rat ileum smooth muscle induced by electrical stimulation in a concentration-dependent manner, whereas the water extracts of Arecae pericarpium(AP), Agastachis herba(AH) and Magnoliae cortex(MC) potentiated the isometric contraction. In the aspirin-induced acute gastritis, the water extracts of MC, AP and CR reduced significantly the gastric juice secretion, gastric juice acidity and pepsin activity. They also showed protective activity of gastric mucosal layer from erosion and petichial hemorrhage in gross and histological examination.
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